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  • Real-time tRNA transit on single translating ribosomes at codon resolution

    Sotaro Uemura, Colin Echeverría Aitken, Jonas Korlach, Benjamin A. Flusberg, Stephen W. Turner, Joseph D. Puglisi

    ... Real-time translation in ZMWs ... ZMWs (Fig. 1a) are nanophotonic confinement structures consisting of circular holes of diameter 50– ...

    Nature 464, 1012-1017 (15 April 2010) doi:10.1038/nature08925 Article

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  • Sequencing in a flash

    Michael Eisenstein

    ... into a working instrument. Their system makes use of nanostructures called zero-mode waveguides (ZMWs), tiny wells in which individual polymerase molecules have been immobilized in fixed orientation. ... , tiny wells in which individual polymerase molecules have been immobilized in fixed orientation. These ZMWs establish small volumes in which each enzyme can be readily imaged with minimal background noise ...

    Nature Methods 6, 114-115 (February 2009) doi:10.1038/nmeth0209-114a Research Highlights

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