Quantitative epigenetics: DNA sequence variation need not apply
Eric J. Richards
Genes Dev. 2009 23: 1601-1605
Access the most recent version at doi:10.1101/gad.1824909

Quantitative epigenetics: DNA sequence variation need not apply

  1. Eric J. Richards,1

+Author Affiliations

  1. Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA


    Two recent reports, including one by Reinders and colleagues (pp. 939–950) in the April 15, 2009, issue of Genes & Development, describe the construction of Arabidopsis recombinant inbred populations that maximize epigenetic rather than genetic variation. The distribution and behavior of phenotypic variation in these populations suggest that stable epialleles can control complex quantitative traits. However, stochastic epimutation and transposon movement in these populations present some unexpected technical hurdles to implementing quantitative epigenetic analysis.



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      Genes Dev. April 15, 2009 23939-950doi:10.1101/gad.524609