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DevBio 9th

Developmental Biology, Ninth Edition

Scott F. Gilbert

© 2010 
711 pages, 699 illustrations

About This Title

Sample chapters available on the Samples Page.

During the past four years, the field of developmental biology has begun a new metamorphosis. The Ninth Edition of Developmental Biology mirrors this shift with a wholly revised text, over 600 new literature citations, and substantial reorganization of content. The introductory section has been streamlined from six chapters to three—one each on developmental anatomy, the mechanisms of gene regulation during differentiation, and cell–cell communication during morphogenesis. Another new feature is the addition of short part openers that address key concerns in developmental biology. These provide an introduction to the subsequent chapters, telling the reader what to expect and placing that information into a specific context. Each chapter ends with a guide to Web-based resources relevant to that chapter’s content, and the Ninth Edition is the first to include a glossary of key terms. Some of the new material in this edition includes: mesenchymal and induced pluripotent stem cells; the transdifferentiation of pancreatic cells; new data on sea urchin micromere specification; the mechanisms whereby Sry and Wnt signaling determine mammalian sex; the memory of cell fate during amphibian limb regeneration; how bats got their wings and how dachshunds got their short legs.

Ninth Edition Features and Supplements

A completely updated text includes fundamental new material that alters what we teach in developmental biology courses.

DevBio Laboratory: Vade Mecum3
Included inside every copy of the book is an online access code for Mary Tyler and Ron Kozlowski’s remarkable resource, DevBio Laboratory: Vade Mecum3. Online access may also be purchased separately.

Companion Website (
Cross-referenced throughout the textbook, this resource provides more information for advanced students, historical, philosophical, and ethical perspectives on issues in developmental biology, videos, interviews, Web links, and updates. The website includes the full bibliography of literature cited in the book, most of which are linked to their PubMed citations. Also, for the Ninth Edition, Susan Singer’s chapter on plant developmental biology has been moved to this location.

Instructor’s Resource Library
The Developmental Biology, Ninth Edition Instructor’s Resource Library contains: all the figures (including photographs) and tables from the textbook in JPEG (high- and low-resolution) and PowerPoint® formats; a video collection; videos, images, and the Instructor’s Guide from DevBio Laboratory: Vade Mecum3; and the Instructor’s Guide to Differential Expressions2.

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About the Author

Scott F. Gilbert, the Howard A. Schneiderman Professor of Biology at Swarthmore College, teaches developmental biology, developmental genetics, and the history of biology. After receiving his B.A. from Wesleyan University, he pursued his graduate and postdoctoral research at The Johns Hopkins University and the University of Wisconsin. Dr. Gilbert is the recipient of several awards, including the first Viktor Hamburger Award for excellence in developmental biology education, the 2004 Alexander Kowalevsky Prize for evolutionary developmental biology, an honorary degree from the University of Helsinki, and the Medal of François I from the Collège de France. He is a Fellow of the American Association for the Advancement of Science, and a corresponding member of the St. Petersburg Society of Naturalists. His research is sponsored by the National Science Foundation and involves the developmental genetic mechanisms by which the turtle forms its shell.

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Value Options

Looseleaf Textbook
The complete full-color Ninth Edition is available in a three-hole punched looseleaf format. Students can take just the sections they need to class and can easily integrate instructor material with the text.
ISBN 978-0-87893-558-1

Interactive eBook
The interactive eBook features a wealth of interactive tools and resources. For instructors, the eBook offers an unprecedented opportunity to easily customize the textbook with the addition of notes, Web links, images, documents, and more. Students can readily bookmark pages, highlight text, add their own notes, and customize the display of the text. All of the Companion Website’s resources are integrated directly into the eBook, so that students can easily access them while reading the text.
ISBN 978-0-87893-412-6, 180-day subscription

CourseSmart eBook
This basic eBook reproduces the look of the printed book exactly, and includes convenient tools for searching the text, highlighting, and adding notes.
ISBN 978-0-87893-409-6, 180-day subscription

For more information on any of these value options, please contact: 

Nancy Asai

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New Material

Developmental biology differs enormously from the field four years ago. Here, by chapter, are some of the exciting new discoveries and principles incorporated into Developmental Biology, Ninth Edition:

I. Principles: Introducing Developmental Biology

Introducing the questions and principles that are the foundation of developmental biology

1. Developmental anatomy

  • Evolutionary developmental biology of bat wings and dachshund legs

2. Developmental genetics

  • Roles of microRNAs in controlling cell identity
  • Histone remodeling
  • Reprogramming exocrine pancreas into beta-cells
  • Dscam splicing
  • Translation initiation

3. Cell–cell communication in development

  • Epithelial–mesenchymal transitions
  • Cell shape change and morphogenesis
  • Elasticity of extracellular matrix regulating differentiation
  • Coordination of cell migration

II. Specification: Introducing Early Embryonic Development

An introduction to the modes of specification and determination used in the animal kingdom

4. Fertilization

  • Soluble PLC-zeta in mammalian fertilization
  • The mechanisms for cortical granule exocytosis
  • Mammalian blocks to polyspermy
  • Regulation of acrosome reactions

5. Early development in selected invertebrates

  • Specification of sea urchin micromeres and recruitment of skeletogenic genes
  • Regulation of sea urchin gastrulation
  • Double-negative gate gene circuits
  • Left–right axis formation in snails, tunicates, and nematodes
  • Mollusk D-quadrant signaling
  • Centrosome-attracting bodies in tunicate development

6. The genetics of axis specification in Drosophila

  • Smaug in maternal-to-zygote transition
  • The bicoid mRNA gradient
  • Cytoskeletal and cell adhesion changes induced by homeotic genes
  • Mechanisms of cellularization
  • Mechanisms of posterior localization
  • Realisator gene pathways

7. Amphibians and fish: Early development and axis formation

  • Cell adhesion and cell shape changes during gastrulation
  • Vg1 signaling for mesoderm and endoderm specification
  • Importance of Wnt11 for dorsal–ventral polarity
  • New pathway of organizer formation
  • Single-cell internalization in zebrafish gastrulation

8. Birds and mammals: Early development and axis formation

  • Intercalation and primitive streak formation
  • How the amniote mesenchyme cells are instructed to ingress into the embryo
  • Specification of chick germ layers
  • How the mammalian inner cell mass separates from the trophectoderm
  • How the embryonic axis is established in the blastocyst

III. Stem Cells: Introducing Organogenesis

An introduction to the stem cell concept, including new material on embryonic and induced stem cells, mesenchymal stem cells, and the construction of stem cell niches

9. The emergence of the ectoderm: CNS and epidermis

  • How the layers of the mammalian cortex are defined and how cells are instructed to reach these layers
  • The developmental regulatory genes that may be involved in primate brain evolution
  • How the hair follicles become spaced and the hair shaft grows
  • EDAR mutations and epidermal appendages
  • Multipotent retinal stem cells and their specification by microRNAs and timing

10. Neural crest cells and axonal specificity

  • Neural crest cell specification by paracrine factors and transcription factors
  • Migrational control of neural crest cells
  • Adrenal cortex formation
  • Reciprocal regulation of facial and brain structures
  • Multipotency of neural crest cells
  • Species-specific facial patterns
  • Transcription factors in neural guidance
  • The Brainbow technique
  • Retinal guidance mechanisms

11. Paraxial and intermediate mesoderm

  • The new cell types (fat, tendons, joints, blood vessels) that are derived from the somites
  • The formation of satellite cells for muscle growth and repair
  • Epiblast muscle precursor cells
  • Head mesoderm and its relationship to neural crest cells
  • Myostatin
  • Somite-derived angioblasts
  • Models of somite periodicity
  • Generation of kidney morphogenetic field
  • Nephron specification

12. Lateral plate mesoderm and endoderm

  • Heart fields and patterning
  • How the heart forms from multipotent stem cells
  • Common endothelial and hematopoietic progenitor cells
  • Formation of blood vessel tubes
  • Angiogenesis and VEGF receptors
  • Angiogenesis blockade in disease and in cancer therapy
  • Contribution of yolk sac to adult hematopoiesis
  • Roles of shear force on cardiac and vessel development
  • Mesoderm-endoderm interactions in gut tube development
  • Control of liver and pancreas development
  • The formation of new blood vessels and the interaction of biomechanical and genetic factors

13. Development of the tetrapod limb

  • The integration and self-regulation of paracrine pathways to enable limb patterning
  • Formation of joints
  • Sonic hedghog regulation and limb outgrowth
  • Tiktaalik
  • Digit identity genes

14. Sex determination

  • Roles of Sry in promoting testis development and blocking ovarian development
  • Role of Wnt4, R-spondin1, and beta-catenin in promoting ovarian development and blocking testis development
  • Sex differences in brain development
  • Fruitless gene function in Drosophila
  • Sexual differentiation in wallabies and chickens
  • Temperature-dependent sex determination

15. Postembryonic development: Metamorphosis, regeneration, and aging

  • Cell fate memory in amphibian limb regeneration
  • Role of neurons in regeneration
  • Aging through epigenetic drift
  • Evolution of larvae
  • Self-regulation of liver regeneration
  • Nuclear envelope defects in aging

16. The saga of the germ line

  • Migration of chick and mammalian germ cells
  • Traveling niche hypothesis
  • Germ cell specification in mice
  • Cohesin in meiosis
  • Regulation of cytostatic factor in frog oocytes
  • Retinoic acid regulation of meiotic initiation
  • Sperm cell niches

IV. Systems Biology and Development

Introducing the integration and extension of developmental biology into the areas of medicine, ecology, and evolution

17. Medical aspects of developmental biology

  • Altered synaptic function in Down syndrome neurons
  • Teratogenesis and recreational drugs
  • Targeting paracrine factor pathways in cancers
  • VEGFR-3 as a target for cancer therapeutics
  • Theories of cancer stem cells
  • Endocrine disruption
  • Medical aspects of induced pluripotent stem cells
  • Stem cell gene therapy
  • Regenerative medicine

18. Developmental plasticity

  • Vibrational signals for treefrog developmental plasticity
  • Developmental symbioses in mammalian gut
  • Neural plasticity
  • Transgenerational effects of environment
  • Trade-offs in development

19. Evolutionary developmental biology

  • Pitx1 and Duffy blood group enhancer modularity and selection
  • How the turtle gets its shell
  • HoxA-11 and the evolution of the mammalian uterus
  • Evolution of the neural crest
  • Bilaterian ancestry
  • Genetic assimilation
  • Co-development and co-evolution

The chapter “Plant developmental biology,” by Susan Singer, has been moved to the book’s dedicated website,

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Pricing and Options

TitlesProduct CodePrice (USD)  
CourseSmart eBook - purchase or request exam copy viaCourseSmart.
Developmental Biology, 9/E Looseleaf Textbook
978-0-87893-558-1$74.95PurchaseRequest Exam Copy
Interactive eBook - purchase via Kagi.
Developmental Biology, 9/E
978-0-87893-384-6$124.95PurchaseRequest Exam Copy
Developmental Biology, 9/E with A Student Handbook for Writing in Biology, 3/E
Bundle available in US and Canada only.
This bundle includes:
Developmental Biology, Ninth Edition
A Student Handbook for Writing in Biology, Third Edition
978-0-87893-536-9$130.40PurchaseRequest Exam Copy
Developmental Biology, 9/E with Bioethics and the New Embryology: Springboards for Debate
Bundle available in US and Canada only.
This bundle includes:
Developmental Biology, Ninth Edition
Bioethics and the New Embryology: Springboards for Debate
978-0-87893-544-4$134.90PurchaseRequest Exam Copy
Developmental Biology, 9/E with FlyCycle 2 DVD
Bundle available in US and Canada only.
This bundle includes:
Developmental Biology, Ninth Edition
Fly Cycle2
Developmental Biology, 9/E with Differential Expressions 2
Bundle available in US and Canada only.
This bundle includes:
Developmental Biology, Ninth Edition
Differential Expressions2: Key Experiments in Developmental Biology (2-DVD set)
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